Saturday, April 24, 2010

Which bacteria are most frequently associated with gram negative sepsis?

Assuming that you don't just mean blood infections, here's a nice list:





Medically relevant Gram-negative bacilli include a multitude of species. Some of them primarily cause respiratory problems (Hemophilus influenzae, Klebsiella pneumoniae, Legionella pneumophila, Pseudomonas aeruginosa), primarily urinary problems (Escherichia coli, Proteus mirabilis, Enterobacter cloacae, Serratia marcescens), and primarily gastrointestinal problems (Helicobacter pylori, Salmonella enteritidis, Salmonella typhi).





Nosocomial gram negative bacteria include Acinetobacter baumanii, which cause bacteremia, secondary meningitis, and ventilator-associated pneumonia in intensive care units of hospital establishments.

Which bacteria are most frequently associated with gram negative sepsis?
Not a definite answer, but [1] below says from a small population: "The most common isolates were Escherichia coli, Staphylococcus aureus, and Streptococcus pneumoniae." E. coli is gram negative while the other two are both gram positive [2][3][4], so I suspect that is the answer.





Ok, I just verified it. From [5]: "E. coli is by far the most common gram-negative bacterium causing sepsis. " So I'm pretty confident that is the answer.





(By the way, if you are looking for a list instead of a single type, [5] also has this: "Klebsiella, Proteus, Enterobacter, Serratia, and E. coli, are all common gram-negative bacteria causing septicemia.")
Reply:Pulmonary intravascular macrophages: their contribution to the mononuclear phagocyte system in 13 species and is most frequently associated with bacterial peptidoglycan-associated lipoprotein and organ dysfunction. Now if I can only pronounce all that!
Reply:It depends on the type of septis. Usually you're looking at ecoli. It's pretty easy to get.





If it is sepis from an animal bite, however, it's like 90% pasteurella.





Got pasteurella from a neighbor's cat I tried to help her medicate. In 8 hours I went from sore to unable to move my arm. And this was after I cleaned the bite properly and everything. Not fun, but not a one of the biology students I have taught thinks animal bites are no big deal now.


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